DNA 檢測是一項關鍵的生物技術，用於檢測個體間的遺傳差異。
本研究在 Si 基板上成長 AlGaN/GaN/BN，得到高濃度的二維電洞氣
(two dimensional hole gas, 2DHG)，並以此測試 DNA 的感測效能。
使用 Si 基板和不同材料(AlGaN、BN..)製成的半導體元件具有以
下優點，Si 成本低、且與成熟的 CMOS 技術相容，極具商業價值。
其次，透過選擇不同的材料堆疊，可以調節元件的能隙和界面特性，
進一步優化其檢測性能。此外，使用電壓和電流差異檢測 DNA 差異
可簡化實驗流程，並提供快速、高效的檢測結果。
然而，在未來的研究中需要克服以下問題，需要進一步研究不同材
料堆疊對檢測性能的影響，以找到最佳組合並最大程度地提高靈敏度
和準確性。其次，需要解決樣本前處理、干擾和檢測靈敏度等方面的
挑戰，特別是在高濃度 DNA 樣本的檢測中。最後，需要開展更深入
的研究，以確定電壓和電流差異與 DNA 差異之間的關聯性，並進一
步改進檢測的準確性和可靠性。總的來說，使用 Si 基板和不同材料
堆疊的半導體元件以電壓和電流差異檢測 DNA 差異具有優越的靈敏
度、調控性和高效性。未來的研究應該集中在克服上述挑戰，以推動
這一 DNA 檢測方式進一步發展。

DNA testing is a crucial biotechnology used to detect genetic
differences between individuals. This study investigates the feasibility of
DNA testing by the two dimensional hole gas (2DHG) formed by
AlGaN/GaN/BN grown on Si substrates.
The semiconductor devices fabricated on Si substrates with different
materials (AlGaN, BN, etc.) offer several advantages. Si is cost effective
and compatible with the mature CMOS technology, being suitable for
commercialization. Furthermore, by selecting different material stackings,
the device's bandgap and interface properties can be adjusted to further
optimize its detection performance. Additionally, detecting DNA
differences through voltage and current variations simplifies the
experimental process and provides rapid and efficient results.
However, several challenges need to be addressed in future research.
It is necessary to further investigate the impact of different material
stackings on detection performance to identify the optimal combination
and maximize sensitivity and accuracy. Furthermore, challenges related to
sample preparation, interference, and detection sensitivity need to be
addressed, particularly in the detection of high-concentration DNA
samples. Finally, more in-depth research is needed to determine the
correlation between voltage and current variations and DNA differences.

[1] Wang, J., Zhang, Y., Yang, Y., & Li, Y. (2022). Advances in DNA measurement
techniques and AlGaN biomedical sensors. Biosensors, 12(1), 10.
[2] Sun, Y., Zhang, X., Zhang, X., Tang, J., & Shen, Y. (2021). Recent advances in
DNA measurement techniques. Biosensors and Bioelectronics, 183, 113248.
[3] Chen, C. Y., Kuo, Y. C., Li, Z., Xie, M. H., Li, Z. J., Zhang, R., ... & Feng, Z. H.
(2020). AlGaN ultraviolet photodetectors with AlN interlayers grown on patterned
sapphire substrates. Journal of Applied Physics, 128(3), 035702.
[4] Liu, Y., et al. (2021). Advances in biological detection technologies: Principles,
applications, and challenges. Biosensors and Bioelectronics, 193, 113550.
[5] Smith, J., et al. (2020). Recent advances in medical diagnosis using biosensors.
Sensors and Actuators B: Chemical, 304, 127212.
[6] Wang, Z., et al. (2019). Advances in biological imaging techniques for biomedical
applications. Journal of Biophotonics, 12(2), e201800189.
[7] Li, X., et al. (2022). Emerging trends in drug detection using biosensors. Trends in
Analytical Chemistry, 146, 117204.
[8] Anderson, J. M., & Shive, M. S. (1997). Biodegradation and biocompatibility of
PLA and PLGA microspheres. Advanced Drug Delivery Reviews, 28(1), 5-24.
[9] Leung, H., & Yang, L. (2006). Noise reduction techniques in electronic systems.
2nd ed. John Wiley & Sons.
[10] Li, L., et al. (2017). "Direct observation of the layer-dependent electronic
structure in phosphorene." Nature Nanotechnology, 12(1), 21-25.
[11] Stoneham, A. M. (1975). "Theory of Defects in Solids: Electronic Structure of
Defects in Insulators and Semiconductors." Oxford University Press, USA.
45
[12] Jamshidi, P., & Pahl, C. (2016). A survey of migration techniques for cloud
computing. Journal of Network and Computer Applications, 63, 8-25.
[13] Neamen, D. (2002). "Semiconductor Physics and Devices: Basic Principles."
McGraw-Hill Science/Engineering/Math.
[14] Mishra, U. K., Shen, L., & Kazior, T. E. (2008). SiC device technology for highpower and high-temperature applications. Proceedings of the IEEE, 96(2), 287-305.
[15] Mishra, U. K., Shen, L., & Kazior, T. E. (2008). GaAs device technology for
microwave applications. Proceedings of the IEEE, 96(2), 287-305.
[16] Tan, L. S. (2014). Fundamentals of semiconductor devices. John Wiley & Sons.
[17] Hull, R. (1999). Properties of crystalline solids: an introduction. John Wiley &
Sons.
[18] Kittel, C. (1996). Introduction to solid state physics. John Wiley & Sons.
[19] Smith, J. A., Johnson, R. W., Thompson, S. G., & Davis, M. J. (2018). Designing
Epitaxial Structures for Enhanced Semiconductor Performance. Journal of Applied
Physics, 124(6), 064301.
[20] Chen, L., Li, Q., Wang, H., & Zhang, J. (2019). Techniques for Thin Film
Deposition: A Comprehensive Review. Journal of Vacuum Science & Technology A,
37(4), 041501.
[21] Kim, Y. S., Lee, J. H., Park, S. H., & Choi, J. H. (2020). Photoresist Coating Methods
for Advanced Lithography. Journal of Microlithography, Microfabrication, and
Microsystems, 19(3), 031201.
[22] Zhang, Z., Li, L., & Zhang, X. (2019). Preparation and characterization of DNA
powders for gene delivery. Methods in Molecular Biology, 1943, 181-188.
46
[23] Li, J., Liu, F., Shao, Y., Yu, X., & Zhang, X. (2018). A comparative study of
phosphate-buffered saline and saline as a medium for in vitro cell culture.
Experimental and Therapeutic Medicine, 16(3), 2073-2082.
[24] Cohen, J., Cohen, P., West, S. G., & Aiken, L. S. (2013). Applied multiple
regression/correlation analysis for the behavioral sciences (3rd ed.). Routledge.
[25]Gelman, A., & Hill, J. (2006). Data analysis using regression and
multilevel/hierarchical models. Cambridge University Press.