超細粒徑微粒濃縮器（UFPC）是目前唯一可同時濃縮細粒徑與超細粒徑微粒之濃縮器，但原始系統之操作仍有許多不方便之處，例如人力耗費、溫度控制不易、濃縮效果不穩定、系統容易損害等。為了改進這些使用上的缺失，本研究已完成此微粒濃縮器操作介面之改善與自動化，包括：飽和蒸汽單元、乾燥系統及冷卻單元操作介面之改善；完成自動控制軟硬體之設計；系統濃縮效率之測試。目前系統可由電腦即時監測並紀錄系統溫濕度、流量、濃度等參數，並由電腦控制飽和蒸汽箱水溫與冷卻循環水之流量。而性能測試之結果發現溫度之控制相當穩定，但濃縮倍率之範圍約為5至16倍，與理論值22倍有所出入，其原因推測可能與空氣中的含水量有某種程度之相關。
本研究所改善完成之UFPC系統已具備長時間無人操作之能力，除了使用者在操作時更加方便之外，也有助於未來從事最佳操作參數探尋與可調整型濃縮倍率等之研究。

The purpose of this study was to maximize the duration of each operation and to minimize the use of manpower while using the UFPC in studies that requires high concentration ambient particles. To achieve that, several new modules were built. A new saturator and a new cooler both based on close-loop-circulation design were constructed to extent the operation; A longer diffusion dryer was used to eliminate the excess water in the minor flow air; Temperature, relative humidity, and flow sensors were added to monitor conditions of the system; A Windows based software was designed to collect information from sensors and to control temperatures at desired levels in the saturator and the cooler. Several tests were conducted to verify the performances of the new of the UFPC. The results showed that the new system was able to continuously operate for hours. The only thing that stops the UFPC for a brief moment is to replace the drying column. The enrichment factors (EFs) tested with artificial and ambient particles were varied from 5 to 16 that theoretically should be 22. The collected data indicated that the EFs were highly correlated with relative humidity in the incoming air (r=0.8 to 0.9). The amounts of water in the air may have strong influences in the growth of particles that later decides whether the particle can be concentrated or not. Before other hard evidences can be found, this explanation, however, remains a guess.

Anderson K. R., Avol E. L., Edwards S. A., Shamoo D. A., Peng R. C., Linn W. S., Hackney J. D., “Controlled Exposures of Volunteers to Respirable Carbon and Sulfuric-Acid Aerosols”, Journal of the Air & Waste Management Association, Vol.42, Iss.6, pp.770-776, 1992.
Andrew J. G., Chong K., Robert B. D., “Concentrated Ambient Air Particles Induce Mild Pulmonary Inflammation in Healthy Human Volunteers”, Am. J. Respir. Crit. Care. Med., Vol.162, pp.981-988, 2000.
Bascom R., Bromberg P. A., Costa D. A., Devlin R., Dockery D. W., Frampton M. W., Lambert W., Samet J. M., Speizer F. E., Utell M., “Health Effects of Outdoor Air Pollution. Part 1”, Am. J. Respir. Crit. Care. Med., Vol.153, pp.3—50, 1996.
Becker S., Soukup J. M., Gilmour M. I., Devlin R. B., “Simulation of Human and Rat Alveolar Macrophages by Urban Air Particles: Effects of Oxidant Radical Generation and Cytokine Production.”, Toxicol Appl. Pharmacol, Vol.141, pp.637-648, 1996.
Buerki P. R. ”Size-Resoled Trace Metal Characterization of Aerosols Emitted by Four Important Source Type in Switzer-Land”, Atmos. Environ., Vol.23, pp.1659-1668, 1989.
Carvalho L. R. F., Souza S. R., Martinis B. S., Korn M., “Monitoring of The Ultrasonic Irradiation Effect on The Extraction of Airborne Particulate Matter by Ion Chromatography”, Analytica Chimica Acta., Vol.317, Iss.1-3, pp.171-179, 1995.
Charles I. E., Mirza U. B., Dhari A. A., “Responses of Alveolar Macrophages to Post-Gulf-War Airborne Dust From Kuwait”, Environment International, Vol.24, Iss.1-2, pp.213-220, 1997.
Ciocco A., Thompson D. J., “A Follow-Up on Donora Ten Years After: Methodology and Findings”, Am. J. Pub. Health, Vol.15, pp.155—164, 1961.
Costa D. L., Lehmann J. R., Frazier L. T., Doefler D., Ghio A., “Pulmonary Hypertension: A Possible Risk Factor in Particulate Toxicity”, Am. J. Respir. Crit. Care. Med., Vol.149, pp.A480, 1994.
Dockery D. W., Pope C. A. III, Xu X., Spengler J. D., Ware J. H., Fay M. E., Ferris B. G., Speizer F. E., “An Association Between Air Pollution and Mortality in Six US Cities”, N. Engl. J. Med., Vol.329, pp.1753—1759, 1993.
Dong W., Lewtas J., Luster M. I., “Role of Endotoxin in Tumor Necrosis Factor a Expression From Alveolar Macrophages Treated with Urban Air Particles”, Exp. Lung Res., Vol.22, pp.577-592, 1996.
Firket J., “The Cause of The Symptoms Found in the Meuse Valley During the Fog of December 1930”, Bull Acad. R. Med. Belg., Vol.11, pp.683—741, 1931.
Godleski J. J., “Mechanisms of Mortality Associated with Particulate Air Pollution”, Transcript of Clean Air Scientific Advisory Committee Public Meeting, Chapel Hill, North Carolina, 1995.
Godleski J. J., Sioutas C., Katler M., Koutrakis P., “Death from Inhalation of Concentrated Air Particles in Animal Models of Pulmonary Disease”, Am. J. Respir. Crit. Care. Med., Vol.153, pp.A15, 1996.
Gore A. T., Shaddick C. W., “Atmospheric Pollution and Mortality in the County of London”, Br. J. Prev. Soc. Med., Vol.12, pp.104—113, 1968.
Gordon T., Gerber H., Fang C. P., Chen L. C., ”A Centrifugal Particle Concentrator for Use in Inhalation Toxicology”, Inhalation Toxicol, Vol.11, pp.101-117, 1999.
Gordon T., Nadziejko C., Chen L. C., Schlesinger R., “Effects of Concentrated Ambient Particles in Rats and Hamsters: An Exploratory Study”, Healthy Effects Institute, Research Report Number 93., 2000.
Kang Y. C., Park S. B., “Preparation of Fine Silver Particles by Decomposing Droplets Produced from Filter Expansion Aerosol Generator”, Journal of Aerosol Science, Vol.26, pp.S605-S606, 1995.
Kang Y. C., Choi J. U., Park S. B., ”Preparation of High Surface Area MgAl2O4 Particles from Colloidal Solution using Filter Expansion Aerosol Generator”, Journal of the European Ceramic Society, Vol.18, Iss.6, pp.641-646, 1998.
Kang Y. C., Park S. B., “Preparation of Zinc Oxide-Dispersed Silver Particles by Spray Pyrolysis of Colloidal Solution”, Materials Letters, Vol.40, Iss.3, pp.129-133, 1999.
Kobzik L., “Lung Macrophages Uptake of Unopsonized Environmental Particles”, J Immunol, Vol.155, pp.367-376, 1995.
Logan W. P. D., “Mortality in London Fog Incident”, Lancet I, pp.336—338, 1953.
Parker C. R., ”Aerosol Science and Technology”, McGraw-Hill Inc., 1993.
Peters A., Doring A., Wichmann H. E., Koening W., “Increased Plasma Viscosity during an Air Pollution Episode: a Link to Mortality”, Lancet, Vol.349, pp.1582-1587, 1997.
Pope C. A. III, Thun M. J., Namboodiri M. M., Dockery D. W., Evans J. S., Speizer F. E., Heath C. W., “Particulate Air Pol-Lution as a Predictor of Mortality in a Prospective Study of US Adults”, Am. J. Respir. Crit. Care. Med., Vol.151, pp.669—674, 1995.
Schwartz J., Dockery D. W., “Increased Mortality in Philadelphia Associated with Daily Air Pollution Concentrations”, Am. J. Epidemiol., Vol.135, pp.12-19, 1992.
Seaton A., Mac L. W., Donaldson K., Godden D., “Particulate Air Pollution and Acute Health Effects”, Lancet, Vol.345, pp.176-178, 1995.
Sioutas C., Koutrakis P., Burton, R. M., “Development of a Low Cutpoint Slit Visual Impactor for Sampling Ambient Fine Particles”, J. Aerosol Sci., Vol.25, Iss.7, pp.1321-1330, 1994.
Sioutas C., Kim S., Chang M. C., “Development and Evaluation of a Prototype Ultrafine Particle Concentrator”, J. Aerosol Sci., Vol.30, Iss.8, pp.1001-1017, 1999.
Yoshizumi K., Hoshi A., “Size Distribution of Ammonium Nitrate and Sodium Nitrate in Atmospheric Aerosol”, Environ. Sci. Technol., Vol.19, pp.258-261, 1985.
陳衍政, “大氣懸浮微粒之細胞毒性研究-微粒粒徑與成分對A549細胞株釋放細胞激素之影響”, 國立台灣大學職業醫學與工業衛生研究所碩士論文, 1999.
吳朗 編, ”感測與轉換：原理、元件與應用”, 台北, 全欣, 1992.
賴耿陽 編, “感測器應用技術：自動化系統工程之尖端科技”, 台南, 復漢, 1992.