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研究生： 邱顯煒
Shian-Wei Chiou
論文名稱： 大鼠坐骨神經電傳導性與拉伸變形關係之研究
The Relationship Between Nerve-Impulse Conduction and Tensile Deformation in Rat Sciatic Nerve
指導教授： 林志光
Chig-Kuang Lin
口試委員:
學位類別： 碩士
Master
系所名稱： 工學院 - 機械工程學系
Department of Mechanical Engineering
畢業學年度： 94
語文別： 英文
論文頁數： 64
中文關鍵詞： 神經 、電傳導性 、拉伸變形
外文關鍵詞： Tensile Deformation, Nerve-Impulse, Nerve
相關次數： 點閱：9  下載：0 
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    • 摘 要
    本研究主旨在探討大鼠坐骨神經電傳導性與拉伸變形的關係，實驗所使用的老鼠品種是 Long-Evan，而使坐骨神經產生變形的方式則是採取拉伸及固定應變兩種實驗。在拉伸實驗中應變速率為 0.0083 與 0.083 s-1。其結果顯示，在兩個不同應變速率下，神經的電傳導性並沒有顯著的差異，且神經電位減少的程度取決於應變的大小而與應變速率無關。在固定應變實驗方面，在三個不同的應變量下 (50%、80%、95%) ，我們發現較高的應變 (95%) 會有最低程度的神經電位衰減以及最少的殘留神經電位；同時也發現在固定應變下神經電位有持續減少的現象發生，此現象顯示大鼠坐骨神經電位，在固定的應變下，和變形造成的傷害有相當大的關係，而與應力大小程度較無直接關係。最後，本研究使用 Boltzmann equation 來分析神經電位與拉伸應變之關係，結果顯示 Boltzmann equation 有相當不錯的描述效果。

    ABSTRACT
    The present study was conducted to investigate the relationship between the in vitro nerve-impulse conduction and applied tensile deformation in sciatic nerves of Long-Evan rat under increasing and constant elongation test. Results showed that the nerve-impulse conduction during increasing elongation test (tensile test) was of no significant difference between two given strain rates, 0.0083 and 0.083 s-1. Such results indicated the compound nerve action potential (CNAP) amplitude drop was dependent on the strain level and independent of strain rate. During constant elongation (stress relaxation) test, a higher constant strain (95%) would generate a lower final CNAP amplitude ratio but a smaller extent of CNAP amplitude drop, compared to the lower constant strain levels (50% and 80%). The continuous drop of CNAP amplitude during stress relaxation under constant deformation implied that the nerve-impulse conduction in rat sciatic nerve was dependent on the development of deformation-induced damage rather than on the stress level. Finally, the relationship between CNAP amplitude ratio and strain under increasing elongation test could be well described by a Boltzmann equation.

    TABLE OF CONTENTS Page LIST OF TABLES IV LIST OF FIGURES V 1. INTRODUCTION 1 1.1 Nerve System 1 1.2 Biomechanical Properties and Nerve-Impulse Conduction of Peripheral Nerves. 1 1.2.1 Tensile Properties of Peripheral Nerves 2 1.2.2 Viscoelastic Properties of Peripheral Nerves 4 1.2.3 Electrophysiological Properties of Peripheral Nerve 6 1.3 Medical Biostatics 8 1.4 Purpose and Scope 9 2. EXPERIMENTAL PROCEDURES 10 2.1 Sample Preparation 10 2.2 Nerve-Impulse Conduction Testing Setup 10 2.3 Nerve-Impulse Conduction Testing under Increasing Elongation 11 2.4 Nerve-Impulse Conduction Testing under Constant Elongation 12 2.5 Microstructural Analysis 13 2.6 Statistical Analysis 13 3. RESULTS AND DISCUSSION 16 3.1 Nerve-Impulse Conduction under Increasing Elongation 16 3.2 Nerve-Impulse Conduction under Constant Elongation 19 3.3 Mathematic Model 22 4. CONCLUSIONS 25 REFERENCES 26 TABLES 29 FIGURES 32

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