共溶劑對β-胡蘿蔔素於超臨界二氧化碳溶解度影響之研究

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研究生：	簡智翔 Chih-Hsiang Jien
論文名稱：	共溶劑對β-胡蘿蔔素於超臨界二氧化碳溶解度影響之研究 Solubility of β-carotene in supercritical CO2 with cosolvent
指導教授：	李亮三 Liang-sun Lee
口試委員:
學位類別：	碩士 Master
系所名稱：	工學院 - 化學工程與材料工程學系 Department of Chemical & Materials Engineering
畢業學年度：	92
語文別：	中文
論文頁數：	80
中文關鍵詞：	共溶劑、二氧化碳、超臨界流體、胡蘿蔔素
外文關鍵詞：	β-carotene, cosolvent, CO2, supercritical
相關次數：	點閱：12 下載：0
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超臨界流體分離技術乃利用溶質在超臨界流體中較大的溶解度的變化來進行，而影響固體溶解度的因素除了溫度、壓力外，共溶劑的添加亦有可能，因此，欲發展此一分離製程，則固體在超臨界流體中的溶解度實驗數據及一個可以準確預測相行為及計算溶質溶解度的熱力學模式是主要的關鍵所在。
本研究以一套半流動式的高壓相平衡實驗裝置在溫度313.15 K ~ 333.15 K以及壓力 15 MPa ~ 28 MPa(150 bar ~ 280 bar)的條件下量測單一β-胡蘿蔔素以及在丙酮、乙醇、正己烷等共溶劑參與下β-胡蘿蔔素在超臨界二氧化碳中的平衡溶解度數據。對於熱力學模式的關聯，選用 Peng-Robinsion 狀態方程式 (PR EOS) 並配合VDW2 混合律，此外，本研究將嘗試幾種以流體密度或無限稀釋溶液理論為基礎的半經驗及其修正模式如Chrastil、Mendez-Santiago和Jiang等，來探討共溶劑濃度對β-胡蘿蔔素溶解度的影響，希望能提供進一步分離程序設計時所需之最適熱力學計算模式。

The solubility of a solid in a supercritical fluid is effected by temperature, pressure. And in some cases, an added cosolvent is utilized in the supercritical fluid extraction process. Therefore, the equilibrium data in supercritical fluids and the appropriate thermodynamic models that can accurately predict the phase behavior of the system are the important information for the design of such process and the selection of optimal operating conditions
In this study, the solubilities of

目 錄
中文摘要                                                                I
英文摘要                                                               II
目錄                                                                  III
圖目錄                                                                  V
表目錄                                                                VII
符號說明                                                               IX
第一章 緒論                                                              1
1-1前言                                                                 1
1-2超臨界流體                                                           1
1-2-1超臨界流體的簡介                                                    1
1-2-2超臨界流體的群聚效應                                                2
1-2-3超臨界流體萃取的分離原理                                            2
1-2-4超臨界流體萃取的應用                                                3
1-3 共溶劑的添加                                                        4
1-4 β-胡蘿蔔素                                                          4
第二章 熱力學理論模式與文獻回顧                                          8
2-1 狀態方程式法                                                        9
2-1-1 利用狀態方程式法計算溶解度                                         9
2-1-2 物性資料的估算的估算                                          11
2-2 半經驗法                                                           14
2-2-1 Chrastil及其修正型方程式                                          14
2-2-2 Mendez-Santiago等人所提及其修正型方程式                           16
2-2-3 Jiang等人所提之方程式                                             16
2-2-4 二氧化碳密度的估算                                                16
2-3 文獻回顧                                                            17
2-3-1 β-胡蘿蔔素+二氧化碳之二成份系統                               17
2-3-2 β-胡蘿蔔素+二氧化碳+共溶劑之三成份系統                        19
第三章 β-胡蘿蔔素相對溶解度量測                                         22
3-1 實驗裝置與流程                                                     22
3-1-1 進料系統                                                      22
3-1-2 平衡系統                                                          22
3-1-3 取樣系統                                                          23
3-1-4 裝置單元介紹                                                      23
3-2 實驗操作程序                                                       25
3-2-1 氣密實驗                                                          25
3-2-2 實驗裝置的操作步驟                                                26
3-3 組成分析                                                           27
3-3-1 HPLC 定量分析方法                                                 27
3-3-2 檢量線製作                                                        28
3-4 數據處理                                                           28
3-4-1 樣品中固體溶質的定量                                          28
3-4-2 二氧化碳的定量                                                    29
3-5 藥品與最適操作條件                                                 29
3-5-1 藥品                                                              29
3-5-2 最適操作條件                                                      30
第四章 β-胡蘿蔔素平衡溶解度量測                                         37
4-1 實驗量測條件                                                       37
4-2 實驗操作程序                                                       37
4-3 數據處理                                                           37
4-3-1樣品中固體溶質與二氧化碳的定量                                     37
4-3-2共溶劑的定量                                                       38
4-4 實驗結果與討論                                           38
4-5 實驗數據的回歸                                                     39
4-5-1 β-胡蘿蔔素＋二氧化碳之二成份系統                                  39
4-5-2 β-胡蘿蔔素＋二氧化碳＋共溶劑之三成份系統                          40
第五章 結論                                                             76
參考資料                                                                77

                                

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