本論文探討利用異質接面光電晶體來偵測牛血清蛋白濃度，內容包含元件光罩的設計以及光電晶體的製作，與在偵測牛血清蛋白濃度應用。針對牛血清蛋白覆蓋在元件照光區時，所量測到的光電流，與未覆蓋牛血清蛋白前所量測到的光電流做比較，並改變牛血清蛋白的濃度進行量測，可得到不同牛血清蛋白濃度的測量趨勢，進而應用在未知濃度的測量評估。而元件的測量條件為，0.8 V 的直流偏壓，850 nm的光源，光源功率為0.75 mW。相同元件也可應用在其他動物的血清蛋白上。

In this work, it was using HPT to detect the BSA concentration. The content contains mask the design and production of HPT, and detection BSA concentration application. When BSA covers in the area phototherapy of device, the measurement photocurrent and not covered before the measurement of bovine serum albumin to compare the photocurrent, and the change BSA concentration to measure, and obtains the different BSA survey tendency, and then application in unknown concentration survey appraisal. And device operating in the 0.8 V DC bias, the light source is 850 nm and the source of power for the importation of 0.75 mW. Device is also applying in other animal`s serum albumins.

[1]生物晶片的緣起, http://www.bio-drchip.com.tw/chip_origin.asp, 2007
[2]K, Sabah, K, Mohsin, Wang, Ping; Liu, Xiaohui; Li, Su-Ling, “Application of Bioinformatics in the Design of Gene Expression Microarrays,”IEEE Compue Socieity,146 – 160, Nov. 2006
[3]R. Moeller,W. Fritzsche,“Chip-based electrical detection of DNA,” IEE Proc.-Nanobiotechnol., Vol.152,No.1, Feb. 2005
[4]Park, K.-Y., Han, S.-W., Kim, M.-S.; Choi, S.-Y, “Development and characteristics of MosFET Protein Chip using nano SAMs,”Electronics Letter,volume 40 Issue3,203-205, Feb. 2004
[5]Chang, Y-J, Chang, C-H, Hu, C-Y, Liao, C-C, “Fabrication of Protein Chip with Ni-Co Alloy Coated Surface,”IEEE SENSORS,117 – 120, Oct.2007
[6]全球生物晶片產物市場及未來, http://cdnet.stpi.org.tw/techroom/market/bio/bio033.htm, 2005
[7]Kumar, S.; Bajpai, R.P.; Bharadwaj, L.M. , “Lab-on-a-chip based on BioMEMS,”IEEE Internation Conference on Intelligent sensing and Information Processing,222 – 226, 2004
[8]M. M. Mac Sweeney1, C. Bertolino1 , H. Berney2 and M. M. Sheehan, “Characterization and Optimization of an Optical DNA Hybridization Sensor for the Detection of Multi-Drug Resistant tuberculosis,”IEEE Annual Internation Conference,1960 – 1963, 2004
[9]Joon M S, Min-S Y, Ho T, “Development of a novel DNA chip based on a bipolar semiconductor microchip system,”Biosensors and Bioelectronics,1447-1453, Jun. 2007
[10]Park, K.-M.; Lee, S.-K.; Sohn, Y.-S.; Choi, S.-Y., “BioFET sensor for detection of albumin in urine,” Electronics Letter,185 – 186, Dec. 2007
[11]Teo, T.H.; Oung, K.-L.; Chen, X.T.; Gao, Z.Q.; Fan, Y.; Yeoh, W.G., “Time-constant-based CMOS readout circuit for DNA detection,” Electronics Letters,400 – 401, Mar. 2008
[12]董德國,陳萬清“光纖通訊”, 東華書局
[13]Yan Z a, Xin C b, Zheng H a, Chunquan Z a, Yifang C c,*, Jiaxiong F a,“Fabrication and characterization of a novel infrared photoconductive sensor in InAlAs/InGaAs heterojunction,” Solid-State Electronics,63–66, Aug. 2007
[14]梁虔碩, “AlGaAs/GaAs PIN/HBT 光檢測器轉阻放大器之積體化光接收器” 碩士論文, 國立中央大學, 2001.
[15]許志豪, “異質接面光電晶體及液相磊晶成長磷化銦鎵之研究” 碩士論文, 國立中央大學, 1993
[16]劉福鯤, “蛋白質自組裝奈米材料作為胺基酸光學異構物辨識之探討” 奈米通訊,國家奈米通訊實驗室, 2003