代謝症候群一年發生率與消失率的危險因子與準則變化之探討

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研究生：	吳翔業 Hsiang-yeh Wu
論文名稱：	代謝症候群一年發生率與消失率的危險因子與準則變化之探討 The Risk Factors and Components Change in Metabolic Syndrome One Year Incidence and Recovery
指導教授：	洪炯宗 Jorng-tzong Horng
口試委員:
學位類別：	博士 Doctor
系所名稱：	資訊電機學院 - 資訊工程學系在職專班 Executive Master of Computer Science & Information Engineering
畢業學年度：	99
語文別：	英文
論文頁數：	53
中文關鍵詞：	發生率、代謝症候群、消失率
外文關鍵詞：	Incednece, Metabolic syndrome, Recovery
相關次數：	點閱：16 下載：0
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近年來，因為飲食文化與生活型態的改變，腦心血管疾病、高血壓、糖尿病等慢
性疾病已慢慢取代傳染性疾病而危害著國人的健康。在過去，一般認為只要血
壓、血脂、血糖只要還在正常範圍都是健康的，但是臨床上，這些病變因子若有
多項趨近異常範圍，慢性疾病還是會慢慢形成。所以在預防醫學的角度，也將視
野往前推進至病前的症狀 – 代謝症候群。
代謝症候群發生率的研究，很少觸及BMI或體重變化以外其他相關因子的變化對
其發生率的影響，也很少研究討論代謝症候群在研究樣本追蹤一段時間後消失的
原因，所以我們收集了2003到2009 壢新醫院於社區健康篩檢計畫所收集社區民
眾的健康檢查資料，利用邏輯回歸的統計方法，來探討其危險因子、判定準則的
改變量與高血脂用藥，對代謝症候群形成及消失的影響。

In recent years, because of the diet culture and the lifestyle change, cardiacerebrovascular
disease, hypertension, diabetes and other chronic diseases have
replaced infectious diseases and slowly endanger people''s health. In past years, we
generally believed that blood pressure, blood lipids and blood glucose still in the
normal range are healthy. However, in clinic, if many risk factors are closer to
abnormal range, the chronic diseases will be occurred. Therefore, in the perspective of
preventive medicine, we more care about the symptoms before disease - Metabolic
Syndrome.
Some metabolic syndrome (MetS) research focused on the association of the
variation of components with the incidence of MetS, except the BMI and weight
change, and few has been reported on recovery of MetS. In this study, we collected
the community outreaching project data during 2003 to 2009 in Li-shin hospital.
And we used the logistic regression to analyse the relationship of the risk factors and
the change of components in one year recovery and incidence of MetS.

摘要............................................................................................................................... I
ABSTRACT ................................................................................................................. II
致謝............................................................................................................................. III
TABLE OF CONTENTS .......................................................................................... IV
LIST OF TABLE ....................................................................................................... VI
LIST OF FIGTURE ................................................................................................. VII
CHAPTER 1 INTRODUCTION ............................................................................. 1
1.1 BACKGROUND ....................................................................................................... 1
1.2MOTIVATION .......................................................................................................... 2
1.3 GOAL ..................................................................................................................... 2
CHAPTER 2 RELATED WORKS .......................................................................... 3
2.1METABOLIC SYNDROME ........................................................................................ 3
2.2 LOGISTIC REGRESSION .......................................................................................... 6
CHAPTER 3 METHODS AND MATERIALS ...................................................... 7
3.1 SYSTEM FLOW ....................................................................................................... 7
3.2 STUDY POPULATION .............................................................................................. 8
3.3ANTHROPOMETRIC MEASUREMENTS AND BLOOD PRESSURE MEASURES .............. 9
3.4 BIOCHEMICAL PARAMETERS ................................................................................ 10
3.5MAJOR LIFESTYLE VARIABLES ............................................................................ 10
3.6 DEFINITIONS OF METABOLIC SYNDROME ............................................................ 10
3.7 STATISTICAL ANALYSIS ........................................................................................ 11
CHAPTER 4 RESULTS ......................................................................................... 14
4.1 STATISTICAL RESULT AT BASELINE ...................................................................... 14
4.2 ONE YEAR INCIDENCE AND RECOVERY ............................................................... 16
4.3 UNIVARIATE AND MULTIVARIATE LOGISTIC REGRESSION ANALYSIS ................... 21
4.3.1 Metabolic Abnormalities ............................................................................. 21
4.3.2 Change of Risk Factors and Components ................................................... 24
V
4.3.3 Medication Use ............................................................................................ 30
CHAPTER 5 DISCUSSION .................................................................................. 34
CHAPTER 6 CONCLUSION AND FUTURE WORKS ..................................... 38
REFERENCES ........................................................................................................... 39

                                

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