本研究利用電腦立體醫學影像技術並配合光學式定位裝置發展一應用於椎莖骨釘植入的手術導引系統，協助醫師對於病患的病情診斷及在手術中的定位更加精確。
本系統主要分為四個步驟：影像三維重建、手術路徑規劃、方位校準與手術導引。在影像三維重建方面，將病患的二維電腦斷層掃描影像重建成三維模型，並同時顯示其正交剖面資訊，協助醫生做病患病情之診斷；之後進行手術路徑規劃，醫師透過軸向剖面與矢向剖面來規劃手術路徑，最後並透過與規劃手術路徑垂直的剖面資訊來檢查手術路徑的安全性；接下來進行方位校準，系統利用ICP演算法來完成病患脊椎與重建之三維脊椎模型之間的曲面對應，藉以求出影像座標與定位裝置座標之間的轉換關係；最後進行手術導引，系統將手術器械的位置即時顯示於影像中，並提供以手術器械軸向方向為法向量並通過手術器械端點之切平面影像，協助醫師更安全的完成手術。
本研究所發展之系統經過三次的系統精度實驗與一次的模擬椎莖骨釘植入手術實驗後，實驗結果顯示系統之平均定位誤差約為0.88±0.50mm，平均角度誤差約為1.34±0.58°；而模擬椎莖骨釘植入手術實驗的結果在經由C-arm影像檢測後，也顯示系統能正確的導引椎莖骨釘植入至安全的位置。

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