| 研究生: |
陳佳俊 Chia-chun Chen |
|---|---|
| 論文名稱: |
以生理資料為基礎的心血管系統模型之建構 Cardiovascular system modeling based on the physiology data |
| 指導教授: |
吳炤民
Chao-Min Wu |
| 口試委員: | |
| 學位類別: |
碩士 Master |
| 系所名稱: |
資訊電機學院 - 電機工程學系 Department of Electrical Engineering |
| 論文出版年: | 2013 |
| 畢業學年度: | 101 |
| 語文別: | 中文 |
| 論文頁數: | 116 |
| 中文關鍵詞: | 心血管系統模型 、模擬 、主動脈瓣膜狹窄 、僧帽瓣膜狹窄 |
| 外文關鍵詞: | Cardiovascular System, Simulation, Aortic Stenosis, Mitral Stenosis |
| 相關次數: | 點閱:7 下載:0 |
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心血管系統模型的用途十分廣泛,常運用在臨床診斷、藥品測試和醫療儀器開發等方面。本研究的目的是以生理資料為基礎建構心血管系統模型,根據生理文獻上的資料將模型中的血管阻力與順應性以等效的電路元件來模擬,進行多個週期的模擬及觀察模擬的結果。除此之外,在模型中加入神經系統的調控,使模型可模擬交感神經對心室體積與血管阻抗的監控,以達到維持血壓的功能。除了模擬正常情況下的生理現象,我們也做了其他兩種病態的模擬,此兩種病態分別為主動脈瓣膜狹窄與僧帽瓣膜狹窄。從結果顯示本論文的心血管系統模型可以成功模擬出正常時的右心臟、左心臟和其它部位血管的血壓以及瓣膜異常的病理特徵,比較模擬結果和文獻與生理書上的資料
,驗證系統模型在模擬上的可行性。
The cardiovascular system models could be widely used in clinical diagnosis, drug testing, development of medical instrumentation, and so on. The purpose of this study is to build a cardiovascular system model based on the physiological data. The equivalent circuit elements were used to model the resistance and compliance of the vascular system, implement the multi-cycle simulation, and observe the simulated results. Furthermore, the neural control was added to regulate simulation of the model. This neural control provided simulation of the autonomic regulation on the blood pressure through the ventricular volume and vascular resistance. In addition to the simulation of normal condition, the model was used to simulate two pathological conditions, i.e., aortic and mitral valve stenoses. Comparison between the results of our simulation and previous literature studies, our results showed that this cardiovascular system model was capable to simulate normal blood pressure of right heart, left heart, other parts of the blood vessels, and pathological features of valve stenosis and indicated its feasibility as a cardiovascular system model.
Anderson, Candce M., Clark, John W., and JR., (1975). "Analog simulation of left ventricular bypass mode control" IEEE Transactions on Biomedical Engineering, Vol. 22, 384-392
Balestreri, Mcella, Czosnyka, Marek, Hutchinson, Peter, Steiner, Luzius A., Smielewski, Piotr, Pickard, John D., (2006). “Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury” Neurocrit Care, Vol. 4, 8-13
Frank, O., (1899). "Die grundform des arterielen pulses erste abhandlung: mathematische analyse" Z. Biol. Vol. 37, 483-526,
Guarini, Marcello, Urzua, Jorge, Cipriano, Aldo, Gonzalez, Waldo, (1998). "Estimation of cardiac function from computer analysis of the arterial pressure waveform" IEEE Transactions on Biomedical Engineering, Vol. 45, 1420-1428
Guyton, Arthur C., and John, E., (2006). Textbook of medical physiology, Phialadelphia: Elsevier Science Health Science
Grodins, Fred S., (1959). "Integrative cardiovascular physiology: a mathematical synthesis of cardiac and blood vessel hemodynamics" Quarterly Review of Biology Vol. 34, 93-116
Hales, S., (1733). “Statistical Essays: Containing Haemostaticks, or an Account of some Hydraulick and Hydrostatical Experiments on the Blood and Blood-Vessels of Animal etc” Vol. 2, Innys and Manby, London.
Hassani, Kamran, Navidbakhsh, Mahdi, and Rostami, Mostafa., (2006). "Simulation of the cardiovascular system using equivalent electronic system" Journal of Biomedical paper, Vol. 150, 105-112
Heldt, Thomas, Shim, Eun B., Kamm, Roger D., Mark, Roger G., (2002). "Computational modeling of cardiovascular response to orthostatic stress" J Appl Physiol, Vol. 92, 1239–1254
Heldt, Thomas, (2004). “Computational model of cardiovascular response to orthostatic stress” Cambridge, MA: MIT, 2004
He, Ying, Liu, Hao, and Himeno, Ryutaro, (2003). “A one-dimensional thermo-fluid model of blood circulation in the human upper limb” Journal of Heat and Mass Transfer, Vol. 47, 2735-2745
Huang, Chih Chung and Wang, Shyh Hau, (2007). “Assessment of blood coagulation under various flow conditions with ultrasound backscattering” IEEE Transactions on Biomedical Engineering, Vol. 54, 2223-2230
Johnson, Leonard R., and Byrme, John H., (2003). Essential Medical Physiology, Amsterdam: Academic Pr
Klabunde, Richard E., (2011). Cardiovascular Physiology Concepts, Philadelphia, Lippincott Williams and Wilkins
Korakianitis, Theodosios, and Shi, Yubing, (2006). "Numerical simulation of cardiovascular dynamics with healthy and diseased heart valves" Journal of Biomechanics, Vol. 39, 1964-1982
Lim, Einl, Dokos, Socrates, Cloherty, Shaun L., Salamonsen, Ribert F., Mason, David G., Reizes, John A., Lovell, Nigel H., (2010). "Parameter-optimized model of cardiovascular rotary blood pump interactions" IEEE Transactions on Biomedical Engineering, Vol. 57, 254-266
Liang, Fuyou, Takagi, Shu, and Himeno, Ryutaro, (2009). "Multi-scale modeling of the human cardiovascular system with applications to aortic valvularand arterial stenoses" Medical & Biological Engineering & Computing, Vol. 47, 743-755
Ottesen, Johnny T., Olufsen, Mette S., and Larsen, Jesper K., (2004). “Applied mathematical models in human physiology” Philadelphia, Society for Industrial and Applies
Ottesen, Johnny T., (1997). “Modelling of the baroreflex-feedback mechanism with time-delay” Journal of Mathematical Biology, Vol. 36, 41-63
Olufsen, Mette S., Ottesen, Johnny T., Tran, Hien T., Ellwein, Laura M., Lipsitz, Lewis A., Novak, Vera, (2005)."Blood pressure and blood flow variation during postural change from sitting to standing: model development and validation" J Appl Physiol, Vol. 99, 1523-1537
Rideout, Vincent C., (1972). "Cardiovascular System Simulation in Biomedical engineering education" IEEE Transactions on Biomedical Engineering, Vol. 20, 101-107
Ritter, A. B., Reisman, S., and Michiak, B. B. (2005). Biomedical Engineering Principles, Taylor & Franics.
Stergiopulos N., Westerhof B. E., and Westerhof, N., (1999). "Total arterial inertance as the fourth element of the Windkessel model" Am J Physiol, Vol. 271, 81-88
Serrador, Jorge M., Picot, Paul A., Rutt, Brain K., Shoemaker, J. Kevin, Bondar, Roberta L., (2000). “MRI measures of middle cerebral artery diameter in conscious human during simulated orthostasis” American Heart Association, 1672-1678
Snyder, M. F., Rideout, Vincent C., and Hillestad, R. J., (1968). "Computer modeling of the human systemic arterial tree" Journal of Biomechanics, Vol. 1, 341-353
Snyder, M. F., and Rideout, Vincent C., (1969). "Computer simulation studies of the venous circulation" IEEE Transactions on Biomedical Engineering, Vol. 16, 325-334
Simaan, Marwan A., Ferreira, Antonio, Chen, Shaohi, Antaki, James F., Galati, David G., (2009). "A Dynamical State Space Representation and Performance Analysis of a Feedback-Controlled Rotary Left Ventricular Assist Device" IEEE Transactions on Control System Technology, Vol. 17, 15-28
Spelde, P.C.I., (2008) “Minimal haemodynamic modeling of the circulation” University of Groningen, Netherlands
Suga, Hiroyuki, and Sagawa, Kiichi, (1974). "Instantaneous pressure-volume relationships and their ratio in the excised, supported canine left ventricle" Circulation Research, Vol. 35, 117-126
Ursino, Mauro, (1999). “A mathematical model of the carotid baroregulation in pulsating condition” IEEE Transactions on Biomedical Engineering, Vol. 46, 382-392
Wetterer, E., (1954). "Flow and pressure in the arterial system, their hemodynamic relationship, and the principles of their measurement" Minn Med, Vol. 2, 77-86
Wang, J. J., and Parker, K. H., (2004). “Wave propagation in a model of the arterial circulation” Journal of Biomechanics, Vol. 37, 457–470
Westerhof, Nicolaas, Bosman, Frederik, Devries, Cornelis J., Noordergraaf, Abraham, (1969). "Analogue studies of the human systemic arterial tree" Journal of Biomechanics, Vol. 2, 121-143
Zaidi, Habib, and Tsui, Benjamin M. W., (2009). "Review of computational anthropomorphic anatomical and physiological models" Proceedings of the IEEE, Vol. 97, 1938-1953
Stuart Ira Fox (2002), 人體生理學, 高美媚, 蔡秀純, 溫小娟, 廖美華, 羅瑋瑜, 葉睿毅, 新文亰開發出版有限公司
蘇仲南 (2010). "教學用電腦模擬生理系統之建構," 碩士論文, 中央大學電機工程學系研究所
白易民 (2006). "生醫系統模擬之線上學習平台研製," 碩士論文, 逢甲大學自動控制工程學系研究所
呂福江 (2006). 病理學, 華杏, 台北市.
李和惠 (2010). 內外科護理學(下), 華杏, 台北市
吳襄、林坤偉 (1997). 生理學大綱, 藝軒圖書出版社, 台灣.
行政院衛生署, (2011). "前二十大死因戶籍縣市鄉鎮別就診統計," http://www.doh.gov.tw/CHT2006/DM/DM2_2.aspx?now_fod_list_no=10058&class_no=440&level_no=3