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研究生: 馬英傑
Indra Tri Mahayana
論文名稱: Investigation of posterior parietal cortex visuospatial control over processing in near and far space using transcranial magnetic stimulation
指導教授: 阮啟弘
Chi-Hung Juan
口試委員:
學位類別: 博士
Doctor
系所名稱: 生醫理工學院 - 認知與神經科學研究所
Graduate Institute of Cognitive and Neuroscience
論文出版年: 2014
畢業學年度: 102
語文別: 英文
論文頁數: 215
中文關鍵詞: 視覺空間注意力跨顱磁刺激儀頂葉皮質遠近空間視覺空間忽略症
外文關鍵詞: far space, near space, visuospatial neglect
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  • 人類大腦使用視覺空間注意力的能力來確認環境中視覺項目的位置。正常大腦的生理特性可以解釋各種行為現象,包含:個人空間、在有害的視覺刺激接近時的退避反應、或是迴避障礙。視覺空間辨識障礙的病人,普遍是頂葉受到損傷所造成的,病人通常會無法辨識和探索出現在對側空間的視覺刺激,此現象稱為視覺空間忽略症。探討頂葉皮質是如何調控視覺空間注意力,有助於了解正常大腦功能的理論基礎。因此,我們使用跨顱磁刺激儀(TMS)比較受試者的神經活動在有無受到干擾狀況下的行為表現,來探討大腦與行為之間的關聯性。本論文主要想探討視覺空間注意力在遠近距離的控制中,頂葉皮質所扮演的角色。遠近距離的辨識是由不同的視覺注意力神經機制所負責,因此也是一個重要的研究議題。


    The fundamental ability of the human brain to locate visual items in the environment depends on visuospatial attention. Normal physiological properties of the brain explain a range of behavioral phenomena including the personal space of humans, the withdrawal reaction to approaching harmful visual stimuli, or avoidance of obstacles. A patient with visuospatial deficits, commonly as a result of parietal damage, experiences failure to acknowledge or explore stimuli toward the contralesional side of space, a phenomenon called visuospatial neglect. Research and investigation of how the parietal cortex controls visuospatial attention may contribute to the theoretical basis of healthy brain function. Hence, using transcranial magnetic stimulation (TMS) we can investigate the relationship between brain and behavior under controlled experimental conditions when comparing behavioral performance with and without local neural activity disruption. This thesis investigated parietal cortex function in visuospatial attention control in near and far space, coding of which is comprised of different neural mechanisms of visual attention and which will be important to investigate further.

    Inside Cover ............................................................................................................................ i Advisor’s recommendation letter ......................................................................................... iii Verification letter .................................................................................................................. iv Chinese Abstract .................................................................................................................... v English Abstract ................................................................................................................... vi Acknowledgments ............................................................................................................... vii Table of Contents ................................................................................................................. ix Table of Figures .................................................................................................................. xiv List of Tables ...................................................................................................................... xvi Chapter 1: General Introduction .......................................................................................... 1 1. 1. Introduction ............................................................................................................ 1 1. 2. The spatial perception of space: near and far space concepts and the role of posterior parietal cortex .................................................................................................. 4 1. 3. The anatomy of parietal cortex............................................................................. 12 1. 3. 1. Inferior parietal lobule (IPL) ............................................................. 17 1. 3. 2. Intraparietal sulcus (IPS) ................................................................... 21 1. 4. The application of transcranial magnetic stimulation (TMS) in cognitive neuroscience ................................................................................................................. 27 1. 5. The purpose & hypothesis of this thesis............................................................... 34 Chapter 2: Dissociating the role of posterior parietal cortex in near and far visuospatial control, investigated by peripheral target visual search tasks ............................................. 39 2. 1. Background .......................................................................................................... 39 2. 1. 1. The presumptive role of posterior parietal cortex in far space. ................ 42 2. 1. 2. Hypothesis ................................................................................................ 46 x 2.2. Methods .................................................................................................................. 47 2. 2. 1. Experiment 1: Investigation of the role of rPPC in far space .................... 47 2. 2. 1. 1. Participants ..................................................................................... 47 2. 2. 1. 2. Apparatus ....................................................................................... 47 2. 2. 1. 3. Stimuli and Design ......................................................................... 48 2. 2. 1. 3. 1. Experiment 1.1 (Formal experiment) .................................. 48 2. 2. 1. 3. 2. Experiment 1.2 (Control experiment) ................................. 51 2. 2. 1. 3. Procedure ........................................................................................ 52 2. 2. 1. 3. 1. Experiment 1 ....................................................................... 52 2. 1. 3. Eye monitoring 2. 1. 3. Eye monitoring2. 2. 1. 3. Eye monitoring2. 2. 1. 3. Eye monitoring 2. 1. 3. Eye monitoring ................................ ........................ 55 2. 2. 1. 3. 2. Experiment 1.2 .................................................................... 55 2. 2. 1. 4. rTMS Procedure and Site localization ........................................... 56 2. 2. 1. 4. 1. rTMS Procedure .................................................................. 56 2. 2. 1. 4. 2. Site localization ................................................................... 57 2. 2. 1. 4. 3. Experiment 1.2 .................................................................... 59 2. 2. 1. 5. Data Analysis ................................................................................. 59 2. 2. 2. Experiment 2 (Follow up experiment): the investigation of rPPC effect in near space using low spatial probability peripheral search array. ......................... 61 2. 2. 2. 1. Participants ..................................................................................... 61 2. 2. 2. 3. Stimuli and design .......................................................................... 62 2. 2. 2. 4. Procedure ........................................................................................ 64 2. 2. 2. 5. rTMS Procedure and Site localization ........................................... 65 2. 2. 2. 6. Data Analysis ................................................................................. 66 2.3. Results .................................................................................................................... 68 2. 3. 1. Experiment 1.1........................................................................................... 68 2. 3. 1. 1. Experiment 1.1: Hemifield analysis ............................................... 70 xi 2. 3. 2. Experiment 1.2 .......................................................................................... 74 2. 3. 3. Experiment 2 (Follow up experiment): rPPC and low spatial probability search array ........................................................................................................... 76 2. 3. 3. 1. Overall analysis ............................................................................. 76 2. 3. 3. 2. Hemifield analysis ......................................................................... 78 2. 3. 3. 3. Search arrays analysis .................................................................... 78 2. 4. Discussion ............................................................................................................ 81 2. 4. 1. The PPC role in far space ......................................................................... 81 2. 4. 2. rPPC effect in near space using low spatial probability visual search task ........................................................................................................................ 88 2. 5. Conclusion ............................................................................................................ 90 Chapter 3: Investigation of the involvement of posterior medial parietal cortex (the precuneus) in near and far visuospatial control using the landmark task. ........................... 93 3. 1. Background .......................................................................................................... 93 3. 1. 1. Anatomy of precuneus .............................................................................. 24 3. 1. 2. The landmark task for the investigation of visuospatial attention ............ 94 3. 1. 3. Presumptive role of precuneus in visuospatial attention........................... 96 3. 1. 4. Hypothesis ................................................................................................ 98 3. 2. Materials and Methods ......................................................................................... 99 3. 2. 1. Participants ................................................................................................ 99 3. 2. 2. Apparatus .................................................................................................. 99 3. 2. 3. Stimuli and Design .................................................................................. 100 3. 2. 4. Procedure ................................................................................................ 101 3. 2. 5. rTMS Procedure and Site localization .................................................... 104 3. 2. 5. 1. rTMS Procedure .......................................................................... 104 3. 2. 5. 2. Site localization ........................................................................... 104 xii 3. 2. 6. Data Analyses .......................................................................................... 107 3. 2. 6. 1. Accuracy analyses ........................................................................ 107 3. 2. 6. 2. Reaction time (RT) analyses ........................................................ 108 3. 3. Results ................................................................................................................. 109 3. 3. 1. Accuracy analyses ................................................................................... 109 3. 3. 2. Reaction time (RT) analyses .................................................................... 113 3. 4. Discussion ........................................................................................................... 114 3. 5. Conclusion .......................................................................................................... 118 Chapter 4: The application of the near and far space concepts in attributing sensory information in observers. .................................................................................................... 119 4. 1. Background ......................................................................................................... 119 4. 1. 1. Neural basis of ‘parieto-dependent’ areas for mirror mechanisms ......... 122 4. 1. 2. Application of the concept of embodiment and empathy in cognitive neuroscience. ....................................................................................................... 126 4. 1. 3. Hypothesis ............................................................................................... 129 4. 2. Methods ............................................................................................................... 130 4. 2. 1. Participants .............................................................................................. 130 4. 2. 2. Apparatus ................................................................................................. 130 4. 2. 3. Procedures ............................................................................................... 132 4. 2. 3. 1. Follow up experiment (Control experiment) ................................ 133 4. 2. 4. Data analysis ............................................................................................ 135 4. 2. 4. 1. Subjective measures analysis ....................................................... 135 4. 2. 4. 2. The MEPs analysis ....................................................................... 136 4. 2. 4. 2. 1. Correlation analysis of subjective measurements and MEPs amplitude change .................................................................................. 136 4. 2. 4. 2. 2. MEPs amplitudes in near and far space ............................ 136 xiii 4. 3. Results ................................................................................................................ 137 4. 3. 1. The correlation of subjective measurements and MEPs amplitude change ................................................................................................................. 137 4. 3. 2. MEPs amplitudes .................................................................................... 139 4. 3. 2. Follow up experiment ............................................................................. 142 4. 4. Discussion .......................................................................................................... 144 4. 5. Conclusion .......................................................................................................... 146 Chapter 5: General Discussion ........................................................................................ 149 5. 1. Results summary ................................................................................................ 149 5. 2. Overall summary ................................................................................................ 154 Chapter 6: Conclusion, study limitations & future directions ......................................... 157 6. 1. Conclusion .......................................................................................................... 157 6. 2. Study limitations ................................................................................................ 158 6. 3. Future directions ................................................................................................. 160 6. 3. 1. Future directions for near and far space experiments ............................. 160 6. 3. 2. Combination of neuroimaging and neurodisruption techniques. ............ 161 6. 3. 3. The potential of TMS application in clinical settings ............................. 166 6. 3. 4. The application of TMS in cognitive neuroscience research and neurocognitive treatment in Indonesia ................................................................ 172 References ......................................................................................................................... 177

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