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研究生: 陳意芳
Yi-Fang Chen
論文名稱: 個人暴露與呼出氣體連續量測系統之研發
Development of a Real-Time Breath-by-Breath Exposure Monitoring System(BBEMS) for Measuring Inhaled and Exhaled Breath Concentrations
指導教授: 王鵬堯
Peng-Yau Wang
口試委員:
學位類別: 碩士
Master
系所名稱: 工學院 - 環境工程研究所
Graduate Institute of Environmental Engineering
畢業學年度: 88
語文別: 中文
論文頁數: 42
中文關鍵詞: 暴露即時吸入呼出
外文關鍵詞: exposure, real-time, inhaled, exhaled
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  • A real-time breath-by-breath exposure monitoring system (BBEMS) for measuring inhaled and exhaled breath concentrations has been developed in this research. The BBEMS system is composed from three major components: two small semi-conductor gas sensors to detect organic gases, a modified mask to hold the sensors in the gas pathways, and a tiny but high data capacity datalogger to store the measured numbers. Several laboratory tests were conducted to verify the usability of the system, and several volunteers were asked to help evaluating the performances of the system. In this research, ethanol was used as the target gas to create a non-toxic exposure environment. In simulated human absorption test, the amount of exposure calculated by the BBEMS showed a good agreement with the actual amount measured by the charcoal tubes(r=0.99). In the actual human exposure test, the high correlation(r = 0.86 to 0.96) between the doses measured by the BBEMS and the actual doses indicated that the BBEMS was capable of measuring chemical doses with certain precision. The real time concentration data in exhaled showed that the BBEMS is a good device for those who need to know the concentrations in each exhaled breath.

    第一章 前言 1 1.1 研究緣起 1 1.2 研究目的與內容 2 第二章 文獻回顧 4 2.1 暴露評估方法 4 2.2 生物偵測技術 5 2.3 呼出氣體量測方法 6 2.3.1 直接採樣方法 6 2.3.2 間接採樣方法 6 2.4 呼出氣體採集設備 7 2.5 呼吸量及乙醇的吸收率 10 2.6 呼出氣中乙醇濃度之影響因子 11 2.7 人體暴露實驗 11 第三章 實驗方法與步驟 13 3.1 資料收集及各單元設計 13 3.1.1 濃度感應單元 13 3.1.2 資料自動記錄單元 15 3.1.3 進行暴露之個人型載具 16 3.2 各單元功能測試 17 3.2.1 標準氣體產生系統的設置 17 3.2.2 濃度感應單元功能測試 19 3.2.2.1 電阻值的調整 19 3.2.2.2 背景測試 19 3.2.2.3 反應時間測試 20 3.2.2.4 穩定性測試 20 3.2.2.5 再現性測試 20 3.2.2.6 濃度校正 21 3.2.3 資料自動記錄單元功能測試 21 3.2.4 進行暴露之個人型載具功能測試 21 3.3 個人暴露系統的整合與系統功能測試 22 3.3.1 吸收模擬系統測試 22 3.3.1.1 系統介紹 23 3.3.1.2 背景測試 23 3.3.1.3 系統吸附測試 23 3.3.1.4 人體吸收模擬試驗 24 3.3.2 呼吸模擬試驗 24 3.3.3 人體暴露試驗 25 3.3.3.1 人體吸收試驗 26 3.3.3.2 人體代謝試驗 27 第四章 結果與討論 31 4.1 各單元材料收集及製作結果 31 4.2 各單元功能測試結果 32 4.2.1 濃度感應單元 32 4.2.1.1 背景測試結果 32 4.2.1.2 反應時間測試結果 33 4.2.1.3 穩定性測試結果 33 4.2.1.4 再現性測試結果 33 4.2.1.5 濃度校正結果 34 4.2.2 資料自動記錄單元測試結果 34 4.2.3 進行暴露之個人型載具測試結果 34 4.3 系統功能測試結果 35 4.3.1 吸收模擬系統測試 35 4.3.1.1 背景測試結果 35 4.3.1.2 系統吸附測試結果 35 4.3.1.3 人體吸收模擬試驗結果 35 4.3.2 呼吸模擬試驗結果 36 4.3.3 人體暴露試驗 37 4.3.3.1 人體吸收試驗結果 37 4.3.3.2 人體代謝試驗結果 40 第五章 結論與建議 41 5.1 結論 41 5.2 建議 42

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