本論文為發展輔助X光乳房攝影之擴散光學量測系統，期望藉由雙成像系統的檢測形式，彌補X光乳房攝影檢測上之不足，以增加乳癌的篩檢率。本研究透過多通道光源和多通道光檢測器切換之掃描平台設計，在實驗室建立雙向式穿越掃描量測系統，此檢測裝置以兩個平板擠壓待測物，縮短光源在組織中傳遞的距離，以提高系統之檢測性，且藉由雙向光源投射與光檢測接收的形式，獲得大量的檢測資訊，作為後續影像重建計算所需。在量測系統檢測上，製作檢測專用之固態假體，並透過均質假體檢測，確認光源與光檢測各通道之檢測誤差，進而校正光功率量測曲線。此外，依不同形式之模擬腫瘤置入物，設計不同大小、不同光學係數對比度及不同深淺位置之非均質假體，經檢測結果比較均質與非均質量測曲線之差異，得知腫瘤置入物造成的光功率變化，藉此驗證量測系統對於光學係數差異之非均質假體具有檢測性。此外，為顯明NIR量測系統與X光乳房攝影為不同的檢測機制，研究中設計矩陣形式之不同光學係數液態與固態假體，驗證兩檢測系統之檢測機制差異，X光乳房攝影是區分假體之密度差異，提供本研究所發展之功能性雙成像檢測系統之正當性。

This study is to develop a diffuse optical measuring instrument to be incorporated with an X-ray mammography system for the aid of obtaining functional images to detect breast tumors. It is expected to use the dual modality imaging system for enhancing the diagnosis of breast tumors. In this thesis, a dual-direction scanning device to project illuminated NIR light with a multiple-channel switching for both sources and detectors was designed and constructed. The device is handled to compress breast-like phantoms by two slabs to shorten the distance between sources and detectors that may enhance the detection of system. Thus the measured intensity and even phase are used to reconstruct optical-property images. For obtaining reliable measurement data, a two-phase procedure was employed to calibrate each detection channel of the system. Three types of inhomogeneous phantoms by varying contrast, size and location of inclusions to background were prepared and tested to investigate the differentiation of measured NIR power with using the constructed instrument. As known, the mammography and the diffuse optical tomography are based upon various physics models, the former using X-ray to distinguish density, and the later using NIR to tell between different optical properties of tissues. Matrix-type phantoms were made and tested by a mammographic system and our constructed diffuse optical measuring instrument respectively to justify the dual-modality imaging system.

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