生物相容性鈦鋯基多孔隙金屬玻璃製作及其性質之研究

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研究生：	李思穎 Si-Ying Li
論文名稱：	生物相容性鈦鋯基多孔隙金屬玻璃製作及其性質之研究 Synthesis and characterization of biocompatibility open-cell TiZr based metallic glass foam
指導教授：	鄭憲清 Shian-Ching Jang
口試委員:
學位類別：	碩士 Master
系所名稱：	工學院 - 機械工程學系 Department of Mechanical Engineering
論文出版年：	2018
畢業學年度：	106
語文別：	中文
論文頁數：	84
中文關鍵詞：	金屬玻璃、熱壓成型、孔隙率、人工骨骼
外文關鍵詞：	metallic glass, bulk metallic glass foam, hot compression forming, porosity
相關次數：	點閱：17 下載：0
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鈦合金具有相當高的生物相容性，穩定性以及高安全性。在醫療骨科植體方面有廣泛的應用，尤其是在骨折手術中所需的骨釘、骨板以及人工骨骼等。但由於鈦合金之楊氏係數(E)與人體的骨頭有相當大的差異，而導致應力遮蔽效應(stress-shielding)造成原本的骨頭萎縮；相較於鈦合金，金屬玻璃(Metallic glass)具有較低的楊氏係數、高彈性變性回彈能力、高硬度等性質，且鈦基金屬玻璃有著出色的生物相容性、低密度以及耐腐蝕性。本研究自鈦鋯系列金屬玻璃中選擇，對人體無害之成分且具較高的玻璃形成能力的Ti42Zr35Si5Sn2.5Co12.5Ta3製作多孔材，藉由參數調整製備出符合骨性細胞長入低楊氏係數之孔隙尺寸及孔隙率。首先將Ti42Zr35Si5Sn2.5Co12.5Ta3合金利用真空旋鑄機製作出鈦基金屬玻璃薄帶，再利用SPEX震動球磨機製作出鈦基金屬玻璃粉體，最後將鈦基金屬玻璃粉體添加不同體積比例之氯化鈉於其過冷溫度區間熱壓成型，並經超音波水洗後製作出鈦基金屬玻璃多孔材，製作出不同孔隙率的鈦基金屬玻璃多孔材，尺寸可達直徑約12 mm及厚度約5 mm。
鈦基金屬玻璃多孔材在孔隙率37.8 %左右的楊氏係數與機械強度和人體骨骼較為接近；分別為楊氏係數可達至24.8 GPa且機械強度為41.4 MPa，並可以透過Gibbson和Ashby的模組，模擬出50 %孔隙率以下鈦基金屬玻璃多孔材的楊氏係數與機械強度之關係。

Recently, Titanium base alloys have already widely used in medical applications, especially the bone nail, metal sutures, and bone implant because of its high biocompatibility, stability, and safety in human body. However, titanium alloys is much higher Young's modulus than human bone. This leads to stress-shielding and causes atrophy of original bones (Because of the Young's modulus mismatch, the surgery often failed due to stress-shielding.). In addition, we should be concerned about the durability, corrosion resistance and safety of Titanium alloys in human body. Compare to Titanium base alloys, Ti-based metallic glass has low Young’s modulus, excellence biocompatibility, low density, high elasticity resilience, and corrosion resistance. This research aims to make bulk metallic glass foam by using the Ti42Zr35Si5Sn2.5Co12.5Ta3 metallic glass because of its high glass forming ability and harmless to human body. At first, Ti42Zr35Si5Sn2.5Co12.5Ta3 alloy ingot was prepared by arc-melting, then re-melted and fabricated into MG ribbon by vacuum melt-spinning process. The MG ribbons were chopped and mechanical milled into MG powders by SPEX milling. Furthermore, the different volume fraction combinations of Ti-based MG powder and NaCl powder were mixed and hot-compressed in to bulk form at the supercooled temperature region of Ti-based MG. Finally, these Ti-based BMGFs with dimension of 12 mm in diameter and 4 mm in thickness were obtained by washing out the NaCl from the hot-compressed bulk samples by ultrasonic cleaning in water. Meanwhile, the results of this study show that the Ti-based BMGF with about 37.8 % porosity has similar value of Young's modulus to human bones.

摘要    I
Abstract    III
致謝    IV
表目錄    VII
圖目錄    VIII
第一章 研究背景    1
1-1    前言    1
1-2    研究動機    1
第二章  理論基礎    4
2-1  金屬玻璃發展    4
2-2  實驗歸納法    6
2-2-1 合金應包含三種以上的元素    6
2-2-2 合金中原子半徑比大於12 %    6
2-2-3 主要成分間的混合熱需為負值    6
2-3  金屬玻璃之製造方法    7
2-3-1 氣態→固態    7
2-3-2 液態→固態    7
2-3-3 固態→固態    8
2-4  金屬玻璃之種類    9
2-5  金屬玻璃之特性    10
2-5-1 熱力學性質    10
2-5-2 機械性質    14
2-5-3 化學性質-耐蝕性    14
2-5-4 磁性質    15
2-5-5 生醫應用    15
2-5-6 生物相容性    15
2-5-7 其他性質    16
2-6  鈦基金屬玻璃之發展與應用    16
第三章  實驗步驟與方法    28
3-1  實驗流程    28
3-2  合金試片製備    28
3-2-1 合金配置    28
3-2-2 合金鑄錠熔製    29
3-2-3 薄帶製作    29
3-2-4 粉體製作    30
3-2-5金屬玻璃多孔材製作    30
3-3  微結構分析    30
3-3-1孔隙率    31
3-3-2 X光繞射分析儀    31
3-3-3 掃描式電子顯微鏡    31
3-3-4 能量射散光譜儀    32
3-4  熱性質分析    32
3-4-1示差掃描熱分析儀    32
3-5  機械性質分析    32
3-5-1 壓縮測試    32
第四章  結果與討論    45
4-1  基材性質    45
4-1-1 X光繞射分析-鈦基金屬玻璃粉體    45
4-1-2 SEM觀察    45
4-1-3 熱性質分析    46
4-2  鈦基金屬玻璃多孔材    46
4-2-1 鈦基金屬玻璃多孔材外觀    47
4-2-2 鈦基金屬玻璃多孔材密度    46
4-2-3孔隙率    47
4-2-4 X光繞射分析    48
4-2-5 SEM觀察    49
4-2-6機械性質分析-壓縮測試    49
第五章  結論    63
第六章 參考文獻    64



                                

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