本論文結合外差干涉術測量的高精確度、快速量測以及相位式表面電漿共振的高靈敏度、高解析度的優點，提出一套新穎的量測技術「波長調制旋光外差干涉術應用於表面電漿共振偵測」。本研究除以電流調制雷射二極體之發光波長產生旋光外差光，降低成本外，並提出差動相位偵測概念，能有效的去除環境對系統的影響，達到高靈敏度及高解析度的系統效能，以滿足生醫檢測之需求。
根據實驗結果進行分析，本系統差動相位對折射率靈敏度為1.21×104(°/RIU)，長時間差動相位穩定度為0.048度(兩倍標準差)，因此本系統對折射率解析度可達4×10-6(RIU)。此解析度已足夠應用於偵測介面微量的生化反應。

A novel optical measurement technology“Wavelength-modulated circular heterodyne interferometry for SPR detection”is proposed. This study combined with heterodyne interferometry of high precision, real time measurement, and surface plasma resonance of high sensitivity and high resolution. This study uses direct modulation of a diode laser wavelength to produce heterodyne light source to reduce the costs, and proposes the concept of differential phase detection, which effectively remove the environmental impact on the system. Thus, this study can reach high-sensitivity and high resolution system effectiveness, to meet the needs of biomedical testing.
According to the results, the sensitivity of the system is 1.21 × 104 (°/RIU) and the long time stability of differential phase is 0.048 degree, so the resolution of refractive index is up to 4 × 10-6 (RIU). This resolution is sufficient to detect the interface of biochemical reactions.

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