| 研究生: |
梁祥發 Xiang-Fa Liang |
|---|---|
| 論文名稱: |
以Lactobacillus reuteri菌發酵glycerol生成reuterin做為生物組織材料天然滅菌劑的探討 |
| 指導教授: |
高振宏
C. Robert Kao |
| 口試委員: | |
| 學位類別: |
碩士 Master |
| 系所名稱: |
工學院 - 化學工程與材料工程學系 Department of Chemical & Materials Engineering |
| 畢業學年度: | 89 |
| 語文別: | 中文 |
| 論文頁數: | 65 |
| 中文關鍵詞: | 滅菌劑 、reuterin 、Lactobacillus reuteri 、生物組織材料 |
| 外文關鍵詞: | reuterin, Lactobacillus reuteri, biological tiss |
| 相關次數: | 點閱:14 下載:0 |
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生物組織材料在臨床上,可以用來暫時性或永久性的取代病人缺損的組織或器官。這些生物組織材料在經過適當的交聯劑交聯處理後,可以減低這些異種生物組織材料來源的抗原性,並增加生物組織材料在植入人體後抵抗酵素分解的能力。然而這些經過交聯劑化學修飾的生物組織材料,在植入人體之前仍需經過適當的滅菌處理,以大量減少或完全去除材料上所帶有的微生物,避免病人遭受致病微生物的感染。然而目前臨床上對於生物組織材料,尚未有一個理想、適合的滅菌方法。
本實驗室目前正著手研究一種新的天然滅菌劑-Reuterin。Reuterin是由人或動物的腸胃道所分離出的乳酸菌Lactobacillus reuteri在厭氧的狀態下發酵glycerol後所產生的滅菌物質。其抑菌作用機制可能與RNA氧化還原
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