台灣地區在過去20年於大腸直腸癌流行病學變化，以人口為基礎研究

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研究生：	林紋曲 Wen-Chu Lin
論文名稱：	台灣地區在過去20年於大腸直腸癌流行病學變化，以人口為基礎研究 Analysis of changing epidemiology of colorectal cancers in the past 20 years: a population-based study in Taiwan
指導教授：	洪炯宗 Jorng-tzong Horng
口試委員:
學位類別：	碩士 Master
系所名稱：	資訊電機學院 - 資訊工程學系 Department of Computer Science & Information Engineering
畢業學年度：	99
語文別：	英文
論文頁數：	63
中文關鍵詞：	異時大腸癌、國民健康局、大腸鏡篩檢
外文關鍵詞：	colorectal cancer screening, Bureau of Health Promotion, metachronous colorectal cancer
相關次數：	點閱：6 下載：0
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大腸鏡篩檢通常是基於台灣流行病學數據。大腸鏡篩檢平均高危人群通常開始在50歲年齡，臨床診斷大腸直腸癌的發生率就變得很重要。由於我們的實驗室獲取台灣衛生署國民健康局癌症登記資料，設計一個以全國人口為基底和新個案數的研究。在研究中，我們分析台灣從1988年至2007年罹患CRC病患統計資料，我們計算大腸癌、直腸癌、左側或右側結腸癌和異時大腸癌病患發生率，比較年齡分布、細胞分化等級和性別的差異。50歲前男生和女生大腸直腸癌的發病率是相似的。雖然大腸直腸癌的發病率較集中在男性，在台灣大腸直腸癌流行病學，男性和女性差異只是左側結腸癌。由於平均壽命延長，個人健康篩檢即使超過75歲是必要實施篩檢。實施結腸鏡來確保是否罹患異時大腸癌，特別是針對第一次手術後，尚未接受完整的大腸鏡檢查，這樣的病人是必要實施篩檢。

Colorectal cancer (CRC) screening programs are usually based on epidemiological data in Taiwan. Screening programs for the average-risk population are usually initiated at the age of 50 years old, just before the incidence of clinically diagnosed CRC becomes important. Since our laboratory obtain the cancer registration data from the Bureau of Health Promotion, Department of Health in Taiwan. Using the data of Taiwan Cancer Registry, we designed a population-based study and the number of cases in our study. In this study, our articles analyze the statistics of patients with CRC in Taiwan from 1988 to 2007. We calculate the incidence of colon cancer and rectum and left-sided and right-sided colon cancer and metachronous colorectal cancer to reveal the specific tendency according to age distribution, grade and the gender differences. In both groups, the CRC incidence was nearly equal before age 50. Although the incidence of total colorectal cancers is male dominant, the actual epidemiology difference of colorectal cancers in Taiwan between male and female is limited in left side colon. Because of the longer average lifespan, screening for healthy individuals who are more than 75 years old is necessary. Surveillance colonoscopic evaluation to ensure the absence of metachronous disease is essential for patients after curative surgery, especially for the patients who did not receive complete colonoscopy before the first operation.

摘要..................................................III
Abstract..............................................IV
誌謝..................................................V
Table of Contents.....................................VI
List of Figures.......................................VII
List of Tables........................................VIII
Chapter 1Introduction.................................1
1.1 Background........................................1
1.2 Motivation........................................3
1.3 Goal..............................................4
Chapter 2 Related Works...............................5
2.1 Recent studies of colorectal cancer by hospital-based. materials.............................................5
2.2 Related tools.....................................9
Chapter 3 Materials and method........................13
3.1 Data source.......................................13
3.2 Statistical analysis..............................17
3.3 Incidence rate....................................18
3.4 Process flow......................................20
Chapter 4 Results.....................................21
4.1 Total CRCs........................................21
4.2 Location of the tumor by gender...................27
4.3 Comparison with index cancer and metachronous cancer................................................37
Chapter 5 Discussion..................................39
5.1 Discussion of the CRCs result.....................39
5.2 Discussion of Metachronous CRCs result............48
Chapter 6 Conclusion..................................52
Reference...................................53

                                

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