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| 研究生： |
陳怡君 Yi-Jiun Chen |
|---|---|
| 論文名稱： |
鑑別藥物最低有效劑量之檢定 Tests for identifying the minimum effective dose |
| 指導教授： |
陳玉英
Yuh-Ing Chen |
| 口試委員: | |
| 學位類別： |
碩士 Master |
| 系所名稱： |
理學院 - 統計研究所 Graduate Institute of Statistics |
| 畢業學年度： | 90 |
| 語文別： | 中文 |
| 論文頁數： | 49 |
| 中文關鍵詞： | 對比檢定 、完全平衡設計 、封閉降階檢定 、最低有效劑量 |
| 外文關鍵詞： | minimum effective dose, contrast, closed step down test |
| 相關次數： | 點閱：7 下載：0 |
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本文探討在一元配置(One-Way Layout)實驗設計中，藥物劑量反應具常態分布情形下鑑別最低有效劑量(Minimum Effective Dose，簡記MED )之檢定，此處的最低有效劑量為具有療效的最小劑量水準。首先根據樣本均數建構一個對比(Contrast)得到一個新的檢定，並且考慮文獻中既有的統計量，進一步提出整合檢定。上述檢定為封閉降階檢定(Closed Step-Down Test)，因此，皆能嚴格地控制族誤差率(Familywise Error Rate )。為了解這些方法的表現，利用蒙地卡羅(Monte Carlo)方法模擬本文所提檢定方法及文獻中某些方法的檢定力(Power)和偏誤(Bias)。最後分析實例資料，藉以說明所提方法之應用。
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