我們成功以鈀金屬催化含氮炔類化合物進行分子內合環形成環戊
烷取代吡咯衍生物，且使用微波反應器輔助可以有效提升產率，最高可
達92%。此方法可應用於合成藥物Ramipril 中的重要結構。

Hydroamination of N-(2-ethynylcyclopentyl)sulfonamide to
give non-aromatic 2,3-dihydropyrroles was achieved by using
PdCl2 as the catalyst. With microwave-assisted heating, up to 92%
isolated yield was obtained from this intramolecular 5-endodig
cyclization. The cyclopentane-fused 2,3-dihydropyrroles were
transformed into the corresponding N-tosyl-pyrrolidine-2-
carboxylic acids.

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