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| 研究生： |
張維妮 Wei-Ni Chang |
|---|---|
| 論文名稱： |
混合模型之最大概似估計與經驗貝氏分析 |
| 指導教授： |
樊采虹
Tsai-Hung Fan |
| 口試委員: | |
| 學位類別： |
碩士 Master |
| 系所名稱： |
理學院 - 統計研究所 Graduate Institute of Statistics |
| 畢業學年度： | 91 |
| 語文別： | 中文 |
| 論文頁數： | 86 |
| 中文關鍵詞： | 表現比率 、最大概似估計法 、經驗貝氏法 、混合模型 、微陣列基因表現 、勝算 、差異表現基因 |
| 外文關鍵詞： | odds, expression ratio, maximum likelihood estimation, cDNA microarray, mixture model, empirical Bayes approach, differential expressions |
| 相關次數： | 點閱：17 下載：0 |
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隨著基因晶片( gene chips )技術的發展，其應用也越加廣泛。 本文分析微陣列(microarray)基因表現資料，比較以兩個不同的三成份混合模型(three-component mixture model)描述來自不同基因殘差資料， 使用最大概似估計(maximum likelihood estimator) 與經驗貝氏法(empirical Bayes approach) 估計模型中之參數，以預測機率(predictive probability)及其勝算(odds)鑑別差異表現基因。並將結果運用於一組實際的微陣列資料中。
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