糖尿病對於41歲以上非轉移性乳癌病患之化學治療毒性及病情影響: 以台灣人口為基礎的世代研究

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研究生：	陳彥君 Yan-jun Chen
論文名稱：	糖尿病對於41歲以上非轉移性乳癌病患之化學治療毒性及病情影響: 以台灣人口為基礎的世代研究 Impact of diabetes on chemotherapy toxicity and outcomes of non-metastatic breast cancer patients aged 41 or above: a population-based cohort study in Taiwan
指導教授：	洪炯宗 Jorng-tzong Horng
口試委員:
學位類別：	碩士 Master
系所名稱：	生醫理工學院 - 系統生物與生物資訊研究所 Graduate Institute of Systems Biology and Bioinformatics
畢業學年度：	99
語文別：	英文
論文頁數：	54
中文關鍵詞：	乳癌、存活率、化療毒性、全民健康保險研究資料庫
外文關鍵詞：	Chemotherapy Toxicity, National Health Insurance Research Database, NHIRD, breast cancer, Survival rate
相關次數：	點閱：5 下載：0
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癌症是一種不正常細胞不受控制的生長和擴散。在過去幾年癌症一直是死亡原因的第一名，在2010年癌症的標準死亡率是131.6 (每十萬人為單位)。在台灣的女性癌症中乳癌是最常見的一種癌症。臨床資料顯示乳癌和糖尿病之間有複雜的關聯，而且有研究指出在乳癌的病人中患有糖尿病的病人有較高的死亡率。然而在針對乳癌病人化療毒性的住院率的研究，目前沒有以台灣人口為基礎的研究。根據以上這些理由，我們的研究會著重於以下幾點: 1. 在台灣乳癌病人中有得糖尿病的病人數。 2. 了解有糖尿病的乳癌患者其存活率的情形。 3.統計乳癌病患因為化療毒性而住院的情況。

Cancer is a group of disease characterized by uncontrollable growth and spread of abnormal cells. In Taiwan, cancer is the first most common cause of death in the past few years. The standardized mortality rate for cancer was 131.6 deaths/100,000 people in 2010. The breast cancer is the most common form of cancer among Taiwanese woman. Preclinical and clinical data suggest complex associations between diabetes and a number of studies have indicated that diabetes is associated with higher mortality in patients with breast cancer. There are no population-based data on hospitalization rate for toxicity from breast cancer chemotherapy in Taiwan. According to above reason, our research will focus on following items: First, the number of breast cancer patients with diabetes. Second, the survival state of patients with diabetes. Third, the hospitalization state of patients received chemotherapy.

Chinese Abstract....................................................................................................................................I
English Abstract....................................................................................................................................II
Table of Contests.................................................................................................................................III
List of Figures …..………………………………......................................……………………………………..………………..IV
List of Tables…...................................…………………………………………………………………………………...………….V
Chapter	1 	INTRODUCTION……………………..…………………………………………………………………………………1
1-1	Background…………………………………………………………………………………………………………………………..1
1-2	Motivation……………………………………………………………………………………………………………………………2
1-3	Research Goal……………………………………………………………………………………………………………………….2
Chapter	2 	RELATED WORKS...............……………………………………………………………………………………....3
2-1	Survival Rates of Breast Cancer Patients with Diabetes........................................................3
2-2	Chemotherapy Toxicity..........................................................................................................4
Chapter	3 	MATERIALS AND METHODS……………………………………………………….....……………….…….….6
3-1 	Data Source………………………………………………………………………………………………………………………6
3-2	NHIRD Field Selection……………………………………………………………………………………………………….6
3-3	Study Population………………………………………………………………………………………………………………6
3-4	Data Extraction and Definitions…………………………………………………………………………………………9
3-5	Statistical Analyses………………………………………………………………………………………….………………10
Chapter	4 	RESULTS…………………………………………………………………………………………………….……………11
4-1	Baseline Characteristics………………………………………………………………………………………………….11
4-2	Diabetes Status with Chemotherapy Use………………………………………………………………………..21
4-3	Chemotherapy Regimens and Toxic Effects………………………………………………………………..……31
Chapter	5 	DISCUSSION…………………………………………………………………………………….………………….....34
REFFERENCES………………………………………………………………………………………………………………38
APPENDIXS…………………………………………………………………………………………………………………………41

                                

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