| 研究生: |
陳勃璁 Bo-Cong Chen |
|---|---|
| 論文名稱: |
通過微小擾動回饋方法抑制空間上的交替現象 Suppression of spatial alternans by small feedback perturbation method |
| 指導教授: |
黎璧賢
Pik-Yin Lai 陳志強 C.K Chan |
| 口試委員: | |
| 學位類別: |
碩士 Master |
| 系所名稱: |
理學院 - 物理學系 Department of Physics |
| 論文出版年: | 2017 |
| 畢業學年度: | 105 |
| 語文別: | 中文 |
| 論文頁數: | 104 |
| 中文關鍵詞: | 心臟交替脈 、空間交替 、非線性控制 、動態控制 |
| 外文關鍵詞: | Cardiac alternans, Spatial alternans, Nonlinear control, Dynamic control |
| 相關次數: | 點閱:25 下載:0 |
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一般認為在心臟動力學行為由規律演變至混沌的過程中會有週期倍增的現象, 稱為倍週期(Period-doubling)。而交替震盪的現象(Alternans) 正是倍週期的開始,因此成為了預測心律不整的重要指標。我們研究了Logistic Coupled Map Lattice 空間上的交替現象,並使用r+r-回饋控制方法進行局部區域控制。我們發現處於過渡狀態交替現象的區域更容易被抑制,也適合做為完全抑制交替現象的起點。最後我們提出了動態控制策略,以控制關鍵區域達到完全抑制空間上的交替現象,大約只需要10% 的控制比例。
It is generally believed that there is a phenomenon of period-doubling when cardiac rhythm undergoes a transition from periodic to chaotic dynamics. Cardiac alternans, which is a period-2 oscillation, has become an important indicator of arrhythmia prediction. In this thesis, we study the spatial alternans in the Logistic Coupled Map Lattice and aim at suppressing local alternans by using the r+r- feedback control method. We find that the transition state of the alternans is easier to be suppressed, and it can serve as the starting point for suppressing whole spatial alternans. Finally, we propose a dynamic control strategy to achieve the suppression spatial of alternans by using only about 10% of the control ratio.
[1] A. Karma, “Physics of cardiac arrhythmogenesis,” Annual Review of Condensed Matter Physics, vol. 4, no. 1, pp. 313–337, 2013. doi: 10 . 1146 / annurev - conmatphys-020911-125112. [Online]. Available: https://doi.org/10. 1146/annurev-conmatphys-020911-125112.
[2] J. G. Restrepo and A. Karma, “Spatiotemporal intracellular calcium dynamics during cardiac alternans,” Chaos: An Interdisciplinary Journal of Nonlinear Science, vol. 19, no. 3, p. 037 115, Sep. 1, 2009, issn: 1054-1500. doi: 10.1063/1.3207835. [Online]. Available: http://aip.scitation.org/doi/10.1063/1.3207835.
[3] E. Alvarez-Lacalle, B. Echebarria, J. Spalding, and Y. Shiferaw, “Calcium alternans is due to an order-disorder phase transition in cardiac cells,” Physical Review Letters, vol. 114, no. 10, p. 108 101, Mar. 12, 2015. doi: 10.1103/PhysRevLett.114.108101. [Online]. Available: https://link.aps.org/doi/10.1103/PhysRevLett.114.108101.
[4] A. Petrie and X. Zhao, “Estimating eigenvalues of dynamical systems from time series with applications to predicting cardiac alternans,” Proc. R. Soc. A, rspa20120098, Jul. 4, 2012, issn: 1364-5021, 1471-2946. doi: 10.1098/rspa.2012.0098. [Online]. Available: http://rspa.royalsocietypublishing.org/content/early/2012/07/03/rspa.2012.0098 (visited on 06/22/2017).
[5] Z. Qu and J. N. Weiss, “Dynamics and cardiac arrhythmias,” Journal of Cardiovascular Electrophysiology, vol. 17, no. 9, pp. 1042–1049, Sep. 1, 2006, issn: 1540-8167. doi: 10.1111/j.1540- 8167.2006.00567.x. [Online]. Available: http : / / onlinelibrary . wiley . com / doi / 10 . 1111 / j . 1540 - 8167.2006.00567.x/abstract.
[6] S. S. Kalb, H. M. Dobrovolny, E. G. Tolkacheva, S. F. Idriss, W. Krassowska, and D. J. Gauthier, “The restitution portrait:” Journal of Cardiovascular Electrophysiology, vol. 15, no. 6, pp. 698–709, Jun. 1, 2004, issn: 1540-8167. doi: 10.1046/j.1540-8167.2004.03550.x. [Online]. Available: http://onlinelibrary.wiley.com/doi/10.1046/j.1540-8167.2004.03550.x/abstract.
[7] Z. Qu, Y. Xie, A. Garfinkel, and J. N. Weiss, “T-wave alternans and arrhythmogenesis in cardiac diseases,” Frontiers in Physiology, vol. 1, Nov. 29, 2010, issn: 1664-042X. doi: 10.3389/fphys.2010.00154. [Online]. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028203/.
[8] S. H. Strogatz, Nonlinear dynamics and chaos: With applications to physics, biology, chemistry, and engineering, 1 edition. Cambridge, Mass: Westview Press, Jan. 19, 2001, 512 pp., isbn: 978-0-7382-0453-6.
[9] K. Kaneko and T. Yanagita, “Coupled maps,” Scholarpedia, vol. 9, no. 5, p. 4085, May 12, 2014, issn: 1941-6016. doi: 10.4249/scholarpedia.4085. [Online]. Available: http : / / www . scholarpedia . org / article / Coupled _ maps (visited on 06/25/2017).
[10] S. Sridhar, D.-M. Le, Y.-C. Mi, S. Sinha, P.-Y. Lai, and C. K. Chan, “Suppression of cardiac alternans by alternating-period-feedback stimulations,” Physical Review E, vol. 87, no. 4, p. 042 712, Apr. 15, 2013. doi: 10.1103/PhysRevE.87.042712. [Online]. Available: https://link.aps.org/doi/10.1103/PhysRevE.87.042712.
[11] S.-N. Liang, D.-M. Le, P.-Y. Lai, and C. K. Chan, “Ionic characteristics in cardiac alternans suppression usingT ± feedback control,” EPL (Europhysics Letters),
vol. 115, no. 4, p. 48 001, 2016, issn: 0295-5075. doi: 10.1209/0295- 5075/115/48001. [Online]. Available: http://stacks.iop.org/0295- 5075/115/i=4/a=48001.
[12] D.-M. Le, Y. T. Lin, Y. H. Yang, P.-Y. Lai, and C. K. Chan, “Cardiac alternans reduction by chaotic attractors inT ± feedback control,” EPL (Europhysics Letters), vol. 117, no. 5, p. 50 001, 2017, issn: 0295-5075. doi: 10.1209/0295-5075/117/50001. [Online]. Available: http://stacks.iop.org/0295-5075/117/i=5/a=50001.
[13] J. M. Pastore, S. D. Girouard, K. R. Laurita, F. G. Akar, and D. S. Rosenbaum, “Mechanism linking t-wave alternans to the genesis of cardiac fibrillation,” Circulation, vol. 99, no. 10, pp. 1385–1394, Mar. 16, 1999, issn: 0009-7322, 1524-4539. doi: 10.1161/01.CIR.99.10.1385. [Online]. Available: http://circ.ahajournals.org/content/99/10/1385 (visited on 06/22/2017).
[14] Z. Qu, A. Garfinkel, P.-S. Chen, and J. N. Weiss, “Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue,” Circulation, vol. 102, no. 14, pp. 1664–1670, Oct. 3, 2000, issn: 0009-7322, 1524-4539. doi: 10.1161/01.CIR.102.14.1664. [Online]. Available: http://circ.ahajournals.org/content/102/14/1664 (visited on 06/28/2017).
[15] M. A. Watanabe, F. H. Fenton, S. J. Evans, H. M. Hastings, and A. Karma, “Mechanisms for discordant alternans,” Journal of Cardiovascular Electrophysiology, vol. 12, no. 2, pp. 196–206, Feb. 1, 2001, issn: 1540-8167. doi: 10.1046/j.1540-8167.2001.00196.x. [Online]. Available: http://onlinelibrary.wiley.com/doi/10.1046/j.1540-8167.2001.00196.x/abstract.
[16] D. J. Watts and S. H. Strogatz, “Collective dynamics of ‘small-world’networks,” Nature, vol. 393, no. 6684, pp. 440–442, Jun. 4, 1998, issn: 0028-0836. doi: 10.1038 / 30918. [Online]. Available: https : / / www . nature . com / nature / journal/v393/n6684/full/393440a0.html (visited on 06/27/2017).
[17] A.-L. Barabási and R. Albert, “Emergence of scaling in random networks,” Science, vol. 286, no. 5439, pp. 509–512, Oct. 15, 1999, issn: 0036-8075, 1095-9203. doi: 10.1126/science.286.5439.509. [Online]. Available: http://science.sciencemag.org/content/286/5439/509 (visited on 06/27/2017).
[18] A. L. Lloyd and R. M. May, “How viruses spread among computers and people,” Science, vol. 292, no. 5520, pp. 1316–1317, May 18, 2001, issn: 0036-8075, 1095-9203. doi: 10 . 1126 / science . 1061076. [Online]. Available: http : / / science . sciencemag . org / content / 292 / 5520 / 1316 (visited on 06/27/2017).
[19] R. Pastor-Satorras and A. Vespignani, “Epidemic spreading in scale-free networks,” Physical Review Letters, vol. 86, no. 14, pp. 3200–3203, Apr. 2, 2001. doi: 10.1103/PhysRevLett.86.3200. [Online]. Available: https://link.aps.org/doi/10.1103/PhysRevLett.86.3200.